New Generation of Hybrid Materials Based on Gelatin and Bioactive Glass Particles for Bone Tissue Regeneration

Hybrid scaffolds based on bioactive glass (BAG) particles (<38 µm), covalently linked to gelatin (G*) using 3-glycidoxypropyltrimethoxysilane (GPTMS), have been studied for bone bioengineering. In this study, two compositions (13-93 and 13-93B20 (where 20% of the SiO2 was replaced with B2O3)) were introduced in matrix. The Cfactor (gelatin/GPTMS molar ratio) kept constant at 500. hybrids obtained found be stable 37 °C solution, condition which pure is liquid. All characterized by vitro dissolution Tris(hydroxymethyl)aminomethane (TRIS) solution (for up 4 weeks) Simulated Body Fluid (SBF) 2 weeks). Samples processed exhibited faster initial significantly precipitation a hydroxyapatite (HA) layer. ion release HA recorded from G*/13-93B20 samples are attributable higher reactivity borosilicate compared silicate glass. MC3T3-E1 cell behavior direct contact investigated, showing that cells able proliferate spread developed biomaterials. Tailoring composition allows us better control material’s dissolution, biodegradability, bioactivity. Bioactive (especially BAG) biocompatible, promising application.